Lose Salvation?
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Can we lose our salvation?  Yes and no.  

No one else can take us out of God's hand except ourselves.

Romans 8:32-37  He who did not spare his own Son, but gave him up for us all—how will he not also, along with him, graciously give us all things?   Who will bring any charge against those whom God has chosen? It is God who justifies.   Who is he that condemns? Christ Jesus, who died—more than that, who was raised to life—is at the right hand of God and is also interceding for us.  Who shall separate us from the love of Christ? Shall trouble or hardship or persecution or famine or nakedness or danger or sword?   As it is written:  “For your sake we face death all day long; we are considered as sheep to be slaughtered.”
   No, in all these things we are more than conquerors through him who loved us.  For I am convinced that neither death nor life, neither angels nor demons, neither the present nor the future, nor any powers, neither height nor depth, nor anything else in all creation, will be able to separate us from the love of God that is in Christ Jesus our Lord.

We are to work out our salvation with fear & trembling.  How? By cooperating with God who wants to change our hearts and deeds.

Phil 2:12-13  Therefore, my dear friends, as you have always obeyed—not only in my presence, but now much more in my absence—continue to work out your salvation with fear and trembling, for it is God who works in you to will and to act according to his good purpose.

The branches in Christ that bear no fruit are chopped off?  The fruit comes from abiding in Christ and letting Him transform us.

John 15:1-4 “I am the true vine, and my Father is the gardener.  He cuts off every branch in me that bears no fruit, while every branch that does bear fruit he prunes so that it will be even more fruitful.  You are already clean because of the word I have spoken to you.  Remain in me, and I will remain in you. No branch can bear fruit by itself; it must remain in the vine. Neither can you bear fruit unless you remain in me."

Bear fruit or die.

Matthew 3:10 John the Baptist said, "The ax is already at the root of the trees, and every tree that does not produce good fruit will be cut down and thrown into the fire."

Jesus is our intercessor and asks for mercy for our fruitlessness, as He tries to coax fruit from us.  But there is a limit.

Luke 13:6-8  Then he (Jesus) told this parable: “A man had a fig tree, planted in his vineyard, and he went to look for fruit on it, but did not find any.  So he said to the man who took care of the vineyard, ‘For three years now I’ve been coming to look for fruit on this fig tree and haven’t found any. Cut it down! Why should it use up the soil?’   “‘Sir,’ the man replied, ‘leave it alone for one more year, and I’ll dig around it and fertilize it.  If it bears fruit next year, fine! If not, then cut it down.’”

The work of the Holy Spirit is our only way to bear fruit and escape the wrath to come.

Matt: 12: 31-37  "And so I tell you, every sin and blasphemy will be forgiven men, but the blasphemy against the Spirit will not be forgiven. Anyone who speaks a word against the Son of Man will be forgiven, but anyone who speaks against the Holy Spirit will not be forgiven, either in this age or in the age to come."
   “Make a tree good and its fruit will be good, or make a tree bad and its fruit will be bad, for a tree is recognized by its fruit.  You brood of vipers, how can you who are evil say anything good? For out of the overflow of the heart the mouth speaks.  The good man brings good things out of the good stored up in him, and the evil man brings evil things out of the evil stored up in him. But I tell you that men will have to give account on the day of judgment for every careless word they have spoken.  For by your words you will be acquitted, and by your words you will be condemned.”

The gifts of the Holy Spirit without the fruit of the Holy Spirit are useless for salvation.  But you need the gifts of the Holy Spirit to know what your Father wants you to do.

Matthew 7:16-24  "By their fruit you will recognize them. Do people pick grapes from thornbushes, or figs from thistles?  Likewise every good tree bears good fruit, but a bad tree bears bad fruit.  A good tree cannot bear bad fruit, and a bad tree cannot bear good fruit. Every tree that does not bear good fruit is cut down and thrown into the fire.  Thus, by their fruit you will recognize them.
    “Not everyone who says to me, ‘Lord, Lord,’ will enter the kingdom of heaven, but only he who does the will of my Father who is in heaven. Many will say to me on that day, ‘Lord, Lord, did we not prophesy in your name, and in your name drive out demons and perform many miracles?’  Then I will tell them plainly, ‘I never knew you. Away from me, you evildoers!’

God plays for keeps when it comes to fruitfulness.

Matthew 21:19  Seeing a fig tree by the road, He (Jesus) went up to it but found nothing on it except leaves. Then he said to it, “May you never bear fruit again!” Immediately the tree withered.

1 Timothy 5:5-6  The widow who is really in need and left all alone puts her hope in God and continues night and day to pray and to ask God for help.  But the widow (in the church) who lives for pleasure is dead even while she lives.

If we divorce ourselves from Jesus after knowing all we can have in Christ, we are doomed.  But ignorance can be an excuse if we fall away.  Peter had the excuse that he didn't believe Jesus would rise from the dead.  Paul had the excuse that he didn't know who Jesus was.

Hebrews 6:4-8   It is impossible for those who have once been enlightened, who have tasted the heavenly gift, who have shared in the Holy Spirit,  who have tasted the goodness of the word of God and the powers of the coming age,  if they fall away, to be brought back to repentance, because to their loss they are crucifying the Son of God all over again and subjecting him to public disgrace.
   Land that drinks in the rain often falling on it and that produces a crop useful to those for whom it is farmed receives the blessing of God. But land that produces thorns and thistles is worthless and is in danger of being cursed. In the end it will be burned.

Here's a balanced position on the whole topic:

2 Timothy 2:11-13   Here is a trustworthy saying:
   "If we died with him, we will also live with him;
   if we endure, we will also reign with him.
   If we disown him, he will also disown us;
   if we are faithless -- he will remain faithful, for he cannot disown himself."